Uruguay produced an assured performance to beat hosts South Africa 3-0 in Pretoria and take a big step towards qualification for the second round.
The South Americans were g a constant threat to Bafana Bafana's goal while also nullifying the tentative attacking threat provided by the hosts who looked out-matched and out-thought.
Diego Forlan scored twice - the first a 30-yard deflected strike and the second a well-taken penalty after Luis Suarez had been fouled by goalkeeper Itumeleng Khune - and Alvaro Pereira added a third goal in injury time.
Uruguay now has four points and sit on top of the table ahead of their final group game with Mexico, where a draw would be enough to qualify.
In contrast, this defeat is South Africa's facing an uphill task to secure a place in the last 16, and a victory over France in the last group fixture is imperative if the hosts are to progress.