Barcelona 3-0 ValenciaLionel Messi grabbed a second half hat-trick for Barcelona on Sunday night.
Valencia held their own in a cagey first half before Messi took centre stage with a wonderful treble.
The visitors never threatened a comeback once Hedwiges Maduro became the seventh Valencia player to be sent off in seven games shortly after Messi's opener.
Real Valladolid 1-4 Real MadridReal Madrid responded with an emphatic 4-1 win at Real Valladolid.
Cristiano Ronaldo put Manuel Pellegrini's side ahead with a trademark free-kick after 28 minutes and two Higuain strikes either side of half-time all but settled the issue with Madrid leading 3-0.
Raul Albiol bundled home a comical own goal before Higuain notched his third goal of the game, tapping in Ronaldo's cross-shot.
Sevilla 1-1 DeportivoSevilla were held at home to a 1-1 draw by fellow high-flyers Deportivo La Coruna.
It started well for the hosts when they took a first-half lead through Federico Fazio.
However, sixth-placed Depor, who are only two points behind the Andalusians, levelled up almost immediately through Adrian Lopez and despite the hosts hitting the woodwork twice and pushing hard for the win in the second half, the spoils were shared.
Spanish Liga Top Six Standings
Team Pl W D L Fr Ag Pts Real Madrid 26 21 2 3 71:21 65 Barcelona 26 20 5 1 64:16 65 Valencia 26 13 8 5 42:29 47 Sevilla 26 13 5 8 39:29 44 Mallorca 26 13 4 9 41:31 43 Deportivo 26 12 6 8 30:28 42