The holders laid on their most complete performance, by some distance, since that fabulous day in May last year when they defeated Manchester United 2-0 to lift the trophy in Rome.
Their first goal came straight from the training ground. Xavi bent a corner to the near post, Thierry Henry flicked it on to the far, and Pique bullishly held off Thiago Motta to stab home.
For the second goal, Iniesta clipped an inside pass to Xavi, whose cushioned volley was measured to land between two defenders and meet the run of Daniel Alves. Alves dinked the ball to the far post and Pedro raced in to volley home.
Barcelona v Inter Milan match report at UEFA.com
Group F Pld Pts Barcelona 5 8 Inter Milan 5 6 Rubin Kazan 5 6 Dynamo Kyiv 5 5